Journal
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
Volume 45, Issue -, Pages 1-13Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.cocis.2019.08.003
Keywords
Short peptides; Self-assembly; Non-covalent interactions; Molecular design; Nanostructures; Characterization techniques; STORM; SANS; Hydrogels
Categories
Funding
- University of Manchester
- China Scholarship Council
- Syngenta
- EPSRC [EP/F062966/1]
- Innovate UK [KTP009043]
- Marie Curie Fellowship ITN grant under SNAL (Small nano-objects for alteration of lipid-bilayers) [608184]
- EPSRC [EP/F062966/1] Funding Source: UKRI
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Owing to their structural simplicity and robust self-assembled nanostructures, short peptides prove to be an ideal system to explore the physical processes of self-assembly, hydrogels, semi-flexible polymers, quenched disorder, and reptation. Rational design in peptide sequences facilitates cost-effective manufacturing, but the huge number of possible peptides has imposed obstacles for their characterization to establish functional connections to the primary, secondary, and tertiary structures. This review aims to cover recent advances in the self-assembly of designed short peptides, with a focus on physical driving forces, design rules, characterization methods, and exemplar applications. Super-resolution microscopy in combination with modern image analysis have been applied to quantify the structure and dynamics of peptide hydrogels, while small-angle neutron scattering and solid-state nuclear magnetic resonance continue to provide valuable information on structures over complementary length scales. Short peptides are attractive in biomedicine and nanotechnology, e.g., as antimicrobials, anticancer agents, vehicles for controlled drug release, peptide bioelectronics, and responsive cell culture materials.
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