Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 58, Issue -, Pages 183-191Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2019.04.006
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Funding
- Research Foundation Flanders (FWO-Vlaanderen) [1S01817N, G0B8817N]
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Fluorescent proteins (FPs) and fluorescent protein-derived biosensors are indispensable tools in life sciences. They make it possible to probe the location, activity, or interaction of molecules of interest from a subcellular to a multicellular scale. The desire for high-resolution and multidimensional information imposes continuously increasing demands on the performance of the employed probes leading to a continued need for optimization and integration of additional features, such as phototransformable behavior. This review highlights the latest advances in FP engineering, which increase throughput and tailor the improvements directly to the envisioned experiments. Additionally, we discuss recent alternative approaches to introduce or alter phototransformable behavior and describe selected applications of phototransformable behavior in biosensors.
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