Journal
CURRENT MEDICINAL CHEMISTRY
Volume 27, Issue 39, Pages 6628-6642Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867326666190816230121
Keywords
Parthenolide; triple negative breast cancer; sesquiterpene lactones; nuclear factor-kappa B; heterogeneity; natural products
Funding
- Fundacao de Amparo a Pesquisa de Minas Gerais (FAPEMIG)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
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Triple Negative Breast Cancers (TNBC) are heterogeneous and aggressive pathologies, with distinct morphological and clinical characteristics associated with their genetic diversity, epigenetics, transcriptional changes and aberrant molecular patterns. Treatment with anti-neoplastic drugs exerts systemic effects with low specificity, and incipient improvement in overall survival due to chemoresistance and recurrence. New alternatives for TNBC treatment are urgent and parthenolide or its analogues have been explored. Parthenolide is a sesquiterpene lactone with promising antitumor effects against TNBC cell lines. This review highlights the importance of parthenolide and its analogue drugs in TNBC treatment.
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