Journal
CURRENT BIOLOGY
Volume 29, Issue 18, Pages 2973-+Publisher
CELL PRESS
DOI: 10.1016/j.cub.2019.07.051
Keywords
-
Categories
Funding
- NIMH [R37MH087027]
- European Research Council (ERC) [StG335880]
- Deutsche Forschungsgemeinschaft (DFG
- German Research Foundation) [276693517 (SFB 1233), SI1332-3/1]
- Centre for Integrative Neuroscience (DFG) [EXC 307]
Ask authors/readers for more resources
Understanding the function of different neuronal cell types is key to understanding brain function. However, cell-type diversity is typically overlooked in electro-physiological studies in awake behaving animals. Here, we show that four functionally distinct cell classes can be robustly identified from extracellular recordings in several cortical regions of awake behaving monkeys. We recorded extracellular spiking activity from dorsolateral prefrontal cortex (dlPFC), the frontal eye field (FEF), and the lateral intraparietal area of macaque monkeys during a visuomotor decision-making task. We employed unsupervised clustering of spike waveforms, which robustly dissociated four distinct cell classes across all three brain regions. The four cell classes were functionally distinct. They showed different baseline firing statistics, visual response dynamics, and coding of visual information. Although cell-class-specific baseline statistics were consistent across brain regions, response dynamics and information coding were regionally specific. Our results identify four functionally distinct spike-waveform-based cell classes in primate cortex. This opens a new window to dissect and study the cell-type-specific function of cortical circuits.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available