Journal
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume 141, Issue -, Pages 43-53Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2019.06.007
Keywords
Non-small cell lung cancer; Nutritional status; Weight loss; Body composition; Muscle wasting
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Funding
- L.I.L.T. (Lega Italiana per la Lotta contro i Tumori)
- Italian Association for Cancer Research - My First AIRC Grant 2013 [14282]
- AIRC-IG [20583]
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Weight loss and depletion of nutritional status are frequent presentation hallmarks in non-small cell lung cancer (NSCLC). Decline in muscle mass is a major component in weight loss and may have both a prognostic and predictive value for survival and treatment-related toxicities. Recent findings suggest that weight and skeletal muscle mass gain during treatment may represent surrogate markers for outcome in advanced NSCLC patients. Herein we present an in-depth view of the impact of nutritional status derangements on NSCLC patients' outcome, focusing on lean body mass variations during disease course. We explored the impact of malnutrition with a major attention on novel treatment options. We reviewed molecular, metabolic and immunological mechanisms underlying muscle-wasting condition, which may exhibit a meaningful targeting potential. Incorporating a specialized and accurate body composition assessment into a comprehensive, patient-centered and tailored intervention will facilitate the achievement of nutritional goals and optimal care for lung cancer patients.
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