Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 23, Issue 17, Pages 5748-5755Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2015.07.012
Keywords
Dengue virus; West Nile virus; Peptide-hybrids; Protease inhibitors
Funding
- National Council for Scientific and Technological Development (CNPq), Brazil
- German Academic Exchange Service (DAAD)
- Deutsche Forschungsgemeinschaft [KL-1356/3-1]
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Dengue virus (DENV) and West Nile virus (WNV) are mosquito-borne arboviruses responsible for causing acute systemic diseases and severe health conditions in humans. The discovery of therapies capable to prevent infections or treat infected individuals remains an important challenge, since no vaccine or specific efficient treatment could be developed so far. In this context, we present herein the synthesis, characterization, biological evaluation and docking studies of novel peptide-hybrids based on 2,4-thiazolidinedione scaffolds containing non-polar groups. The most promising compound has an IC50 of 0.75 mu M against WNV protease, which represents a seventyfold improvement in activity compared to our previously reported compounds. Experimental results and docking studies are in agreement with the hypothesis that a non-polar group in the scaffold is important to obtain interactions between the inhibitors and a hydrophobic pocket in the substrate recognition region of the DENV and WNV NS2B-NS3 serine proteases. (C) 2015 Elsevier Ltd. All rights reserved.
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