Journal
CLINICAL IMMUNOLOGY
Volume 205, Issue -, Pages 116-124Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2019.06.006
Keywords
Exosomes; Type 1 diabetes mellitus; Multiple sclerosis; Systemic lupus erythematosus; Rheumatoid arthritis; Sjogren's syndrome; Potential therapeutic applications
Categories
Funding
- State Key Laboratory of Natural Medicines [SKLNMBZ201403]
- National Science and Technology Major Projects of New Drugs in China [2012ZX09103301-004, 2014ZX09508007]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Double First-Class University project
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Autoimmune diseases are caused by self-immune responses to autoantigens, which damage body tissues and severely affect the patient's quality of life. Therapeutic drugs are associated with adverse side effects and their beneficial effects are limited to specific populations. Evidence indicates that exosomes which are small vesicles secreted by most cell types and body fluids, and may play roles in both immune stimulation and tolerance since they are involved in many processes such as immune signaling, inflammation and angiogenesis. Exosomes have also emerged as promising tools for therapeutic delivery, given their intrinsic features such as stability, biocompatibility and a capacity for stealth. In this review, we summarize existing literature regarding the production, efficacy, action mechanism, and potential therapeutic uses of exosomes in the contexts of autoimmune diseases such as type 1 diabetes mellitus, multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and Sjogren's syndrome.
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