Journal
CLINICA CHIMICA ACTA
Volume 495, Issue -, Pages 191-197Publisher
ELSEVIER
DOI: 10.1016/j.cca.2019.03.1634
Keywords
Platelet activation; PAC-1; TACE; Radical resection; Postoperative prognosis
Categories
Funding
- National Natural Science Foundation of China [81772263, 81572064, 81672839, 81472676]
- Key Developing Disciplines of Shanghai Municipal Commission of Health and Family Planning [2015ZB0201]
- Shanghai Science and Technology Commission [16411952100, 14DZ1940302, 1411970200, 14140902301, 14DZ1940300, 14411970200]
- National Key Research and Development Program of China [2016YFF0101405]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA12020103, XDA12020105]
- National High Technology Research and Development Program (863 Program) of China [2015AA020401]
- State Key Program of National Natural Science of China [81530077]
- Specialized Research Fund for the Doctoral Program of Higher Education and Research Grants Council Earmarked Research Grants Joint Research Scheme [20130071140008]
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Background: The venous thromboembolism, which may be caused by increased platelet activation, is a risk factor for tumor prognosis. We determined the platelet activation status for diagnosis and predicting postoperative prognosis of hepatocellular carcinoma. Methods: We conducted a prospective study of 191 patients diagnosed with HCC at Zhongshan Hospital from April 2016 to July 2016 as well as 99 healthy people. The platelet activation status was assessed by 2 platelet markers, PAC-1 and CD62p, using flow cytometry. The patients were treated with TACE or resection and monitored for >= 6 months. The diagnostic value of marker-positive platelets was determined by the receiver operating characteristic curve and the postoperative value were analyzed using the Kaplan-Meier method and COX regression model. Results: All the 3 groups with high levels of marker-positive platelets were likely to be diagnosed with HCC and the PAC-1(+) percentage had the best efficacy. The univariate analysis showed that the levels of PAC-1(+) and CD62p(+) platelets was risker factors for poor postoperative prognosis after both TACE and resection. Moreover, the multivariate analysis revealed that the level of PAC-1(+) platelets was an independent risk factor for poor prognosis. Conclusions: The PAC-1(+) percentage of platelets is a new indicator for diagnosis and predicting postoperative prognosis.
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