Journal
CLINICA CHIMICA ACTA
Volume 495, Issue -, Pages 331-337Publisher
ELSEVIER
DOI: 10.1016/j.cca.2019.04.082
Keywords
Liquid biopsy; Exosome; lncRNA; Cancer
Categories
Funding
- Non-profit Technology Research Program of Zhejiang Province [LGF18H160006]
- Natural Science Foundation of Zhejiang Province [LQ18H200001]
- Natural Science Foundation of Ningbo City [2018A610204, 2017A610247]
- Scientific Innovation Team Project of Ningbo City [2017C110019]
- National Undergraduate Training Program for Innovation and Entrepreneurship [201711646018]
- K.C.Wong Magna Fund in Ningbo University
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Despite many advances in diagnostics and multimodal treatment (surgery, radiotherapy, chemotherapy), cancer still remains one of the most important public health challenges worldwide because of the associated morbidity and mortality. Liquid biopsy has been developed to detect cancer at an early stage based on minimally invasive and serial body fluid tests with the advantage of following tumor evolution in real time. Circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), circulating cell-free noncoding RNAs (cfRNAs) and circulating exosomes represent the major components of liquid biopsy analysis. Liquid biopsy already has been implemented in cancer management, and most studies thus far are mainly focused on CTCs and ctDNA. In fact, the circulating long noncoding RNAs (lncRNAs) in exosomes have been discovered and confirmed to be closely related to tumorigenesis, metastasis and therapy. Thus this review is mainly focused on the clinical potential of circulating exosomal lncRNAs as a source of liquid biopsy biomarkers in cancer diagnosis, prognosis, and response to treatment, offering novel insights into the precision medicine of oncology.
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