Journal
CHINESE JOURNAL OF CHEMISTRY
Volume 37, Issue 10, Pages 1009-1014Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.201900310
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Funding
- National Natural Science Foundation of China [2167020084, 21673110]
- Innovation & Entrepreneurship Talents Plan of Jiangsu Province
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Silylated fluoroalkenes are important synthetic intermediates with complementary reactivity, which play a key role in the construction of natural products, pharmaceuticals, and manmade materials. Converting the normally highly stable fluoroalkenes into silylated fluoroalkenes by selective defluorosilylation is a challenging task. Herein, we report a simple, inexpensive and robust defluorosilylation of a variety of fluoroalkenes with silylboronates in the presence of alkoxy base to directly synthesize various silylated fluoroalkenes. The protocol features mild and safe reaction conditions that avoid a catalyst, a transition metal, a ligand, and high reaction temperature and tolerates a wide scope of fluoroalkene substrates without compromising the efficiency. Density functional theory calculations show that transient silyl anion complex undergoes an S(N)2' or S-N(V) substitution, which is responsible for this base-mediated defluorosilylation.
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