Journal
CHINESE CHEMICAL LETTERS
Volume 31, Issue 6, Pages 1654-1659Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2019.09.018
Keywords
Carbon quantum dots (CQDs); Functional materials; Biocompatibility; Fluorescence bioimaging; Biodistribution
Categories
Funding
- National Natural Science Foundation of China [81970985, 81771122, 81601613, 21501123]
- Science & Technology Support Program of Sichuan Province [2018SZ0037, 19YYJC2625]
- Graduate Student's Research and Innovation Fund of Sichuan University [2018YJSY108]
- China Postdoctoral Science Foundation [2018M640931]
- Science & Technology Key Research and Development Program of Sichuan Province [2019YFS0142]
Ask authors/readers for more resources
The carbon quantum dots (CQDs) and their functionalized materials are promising in biomedical field because of their unique properties; meanwhile, a growing concern has been raised about the potential toxicity of these modified materials in biosystem. In this study, we synthesized original CQDs and two common functionalized CQDs including N-doped CQDs (NCQDs) and folic acid-modified CQDs (FA-CQDs), and compared the toxicity and biocompatibility with each other in vitro and in vivo. L929, C6 and normal cell MDCK were selected to detect the adverse reaction of these materials in vitro. No acute toxicity or obvious changes were noted from in vitro cytotoxicity studies with the dose of these CQD materials increasing to a high concentration at 1 mg/mL. Among these materials, the FA-CQDs show a much lower toxicity. Moreover, in vivo toxicity studies were performed on the nude mice for 15 days. The experimental animals in 10 or 15 mg/kg groups were similar with animals treated by phosphate buffer solution (PBS) after 15 days. The results of the multifarious biochemical parameters also suggest that the functionalized products of CQDs do not influence the biological indicators at feasible concentration. Our findings in vitro and in vivo through toxicity tests demonstrate that CQDs and their modified materials are safe for future biological applications. (c) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available