Journal
CHEMICAL ENGINEERING JOURNAL
Volume 382, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2019.122986
Keywords
3D printing; Cartilage decellularized matrix; Electrospinning fiber; 3D scaffold; Tissue engineering
Categories
Funding
- National Key Research and Development Program of China [2017YFC1103900]
- China Postdoctoral Science Foundation [2017M621495]
- National Natural Science Foundation of China [81571823, 81570089]
- Key Research and Development Program of Shandong Province [2016GGB14002]
- Shanghai Committee of Science and Technology [15DZ1941600]
- Program for Shanghai Outstanding Medical Academic Leader
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Cartilage decellularized matrix (CDM) is considered a promising biomaterial for fabricating cartilage tissue engineering scaffolds. An ideal CDM-based scaffold should possess customizable 3D shape for complex tissue regeneration and proper pore size for cell infiltration, as well as provide mechanical support for cell growth. 3D printing is an efficiently technique for preparing customizable 3D scaffolds, however, fabricating CDM-based 3D-printed scaffolds with customizable shapes, proper pore structure and satisfactory mechanical properties remains a challenge. In the current study, to achieve customizable CDM-based 3D scaffolds, CDM was successfully processed into inks suitable for 3D printing. Further, the poor mechanics of CDM-based scaffolds were significantly improved by adding electrospinning fiber into the CDM-based inks for 3D printing. Importantly, the 3D-printed electrospinning fiber-reinforced CDM-based scaffold presented good biocompatibility and can enhance repair articular cartilage defects in rabbits. The current study provides a novel strategy for printing electrospinning fiber-reinforced CDM-based scaffolds for tissue regeneration.
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