Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 77, Issue 4, Pages 593-605Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-019-03288-x
Keywords
Pattern recognition; Self-receptor; Autoimmunity; Tolerance
Categories
Funding
- NIGMS NIH HHS [R01 GM032373, R37 GM032373] Funding Source: Medline
- NIH HHS [GM32373] Funding Source: Medline
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung [310030_184720] Funding Source: Medline
- Swiss National Science Foundation (SNF) [310030_184720] Funding Source: Swiss National Science Foundation (SNF)
Ask authors/readers for more resources
The mammalian immune system evolved to tightly regulate the elimination of pathogenic microbes and neoplastic transformed cells while tolerating our own healthy cells. Here, we summarize experimental evidence for the role of Siglecs-in particular CD33-related Siglecs-as self-receptors and their sialoglycan ligands in regulating this balance between recognition of self and non-self. Sialoglycans are found in the glycocalyx and extracellular fluids and matrices of all mammalian cells and can be considered as self-associated molecular patterns (SAMPs). We also provide an overview of the known interactions of Siglec receptors and sialoglycan-SAMPs. Manipulation of the Siglec-SAMP axis offers new therapeutic opportunities for the treatment of inflammatory conditions, autoimmune diseases and also cancer immunotherapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available