The microbiome: A target for Alzheimer disease?

Although recent accumulating data have suggested that gut microbiota associates with Alzheimer disease (AD) pathogenesis, it is not yet clear how alterations in the gut microbiota mechanistically contribute to different aspects of AD pathology. Here, Wang et al. identified that infiltrating peripheral immune cells facilitated by gut microbiota imbalance in mouse models of amyloidosis are associated with changes in behavior and AD-related pathology.