Journal
CARCINOGENESIS
Volume 41, Issue 5, Pages 541-550Publisher
OXFORD UNIV PRESS
DOI: 10.1093/carcin/bgz152
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Funding
- National Nature Science Foundation of China [81672781, 31560312, 81702746]
- Startup Fund for Distinguished Scholars from Nankai University
- Science and Technology Program of Guangzhou [201807010003]
- Science and Technology Department of Guangdong Province of China [2017A030313890, 2016A030310088]
- China Postdoctoral Science Foundation [2017M612839]
- Fundamental Research Funds for the Central Universities [21616323, 21617433]
- Program of Introducing Talents of Discipline to Universities (111 Project) [B16021]
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N6-methyladenosine (m6A) is one of widespread post-transcriptional mRNA modifications in eukaryotes and the m6A modification plays critical roles in various human cancers. However, the role of m6A-binding proteins in cancer metabolism remains elusive. Here, we report that YTH domain family 2 (YTHDF2) is upregulated in lung cancer tissues, promotes lung cancer cell growth and enhances the pentose phosphate pathway (PPP) flux, which is crucial for tumor growth. Mechanistically, YTHDF2 directly binds to the m6A modification site of 6-phosphogluconate dehydrogenase (6PGD) three prime untranslated region (3'-UTR) to promote 6PGD mRNA translation in lung cancer cells. Collectively, our data indicate that YTHDF2 acts as a tumor promoter to enhance tumor growth via facilitating 6PGD mRNA translation.
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