Journal
CARBOHYDRATE POLYMERS
Volume 220, Issue -, Pages 1-11Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2019.05.037
Keywords
Chitosan; Schiff bases; Salicylaldehyde; Glycidol; Antimicrobial; Antitumor activity
Categories
Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brazil (CAPES) [001]
- FAPESP [2015/09299-7]
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Chitosans are versatile biopolymers recognized for their wide range of biological activities. However, the low solubility in neutral and basic solutions restricts the applications. Thus amphiphilic biopolymeric Schiff bases from chitosans, salicylaldehyde and glycidol were successfully synthesized and characterized using H-1-NMR, UV/Vis, FTIR, TG/DTG-DTA and tested for their antimicrobial activities against plant pathogenic microorganisms and human breast cancer cells (MCF-7). Overall, functionalization of chitosans with salicylaldehyde and glycidol with different molecular weight ((M) over bar (w)) was performed to improve the biological actives of chitosans. Thus the biological activity of the new amphiphilic compounds prepared in this work were evaluated regarding microorganisms with agricultural relevance and tumor cells. The biopolymeric amphiphilic Schiff bases showed significant effects against Pseudomonas syringae (IC50 < 5 mu g mL(-1)) compared to the natural chitosans with medium (M) over bar (w) (CHM 223 kDa) and low (M) over barw (CHL 64 kDa), which had IC50 values of 42 and 37 mu g mL-1, respectively. In addition, they improved antitumor activity against tumor cells compared to the natural chitosan.
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