Journal
CANCER LETTERS
Volume 459, Issue -, Pages 186-191Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2019.114425
Keywords
Gut microbiota; NAFLD; Metabolome; Immunity; Gut-liver axis; NAFLD-HCC
Categories
Funding
- RGC-GRF Hong Kong [14111216, 14163817]
- RGC-CRF Hong Kong [C4041-17GF, C7026-18G, C7065-18G]
- CUHK direct grant for research, Hong Kong
Ask authors/readers for more resources
The gastrointestinal tract represents one of the largest interfaces between the host and environmental factors. It contains a vast and complex community of microbes, forming what is collectively known as the microbiota. This gut microbiota plays a pivotal role in the maintenance of health, and 'dysbiosis' of the gut microbiota, commonly considered as perturbation of microbiota diversity and composition, has been associated with intestinal and extra-intestinal diseases, including non-alcoholic fatty liver disease (NAFLD) and its associated hepatocellular carcinoma (NAFLD-HCC). In this review, we highlight microbiota dysbiosis and the microbiota-host interactions that link to the pathogenesis of NAFLD and NAFLD-HCC. We discuss the potential therapeutic implications of the gut microbiota in the progression of NAFLD-HCC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available