Journal
CANCER INVESTIGATION
Volume 37, Issue 9, Pages 489-500Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07357907.2019.1662434
Keywords
Imipramine; prostate cancer; radiotherapy; cell index; oxidative stress; EAG1 channel
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Funding
- Research Fund of Mersin University in Turkey [2017-2-AP4-2537]
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Prostate cancer is the most common cancer and leading cause of cancer death for males. Imipramine (IMI), which is a tricyclic antidepressant, has also been shown to has antineoplastic effect. This study was performed to investigate the radiosensitizing effect of IMI on DU145 prostate cancer cell. Cells were divided into 4 groups. Cell index, apoptotic activity, cell cycle arrest, oxidative stress and EAG1 channel currents were determined in all groups. Our findings showed that combined treatment with IMI and radiotherapy (RAD) did not enhance radiosensitivity of DU145 cells but as unexpected finding, treatment of IMI alone was more effective in DU145 cells.
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