Journal
CANCER INVESTIGATION
Volume 37, Issue 9, Pages 440-452Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07357907.2019.1663208
Keywords
Ovarian cancer; ascites; effusion; microRNA; tumor
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Funding
- Charles University, Prague (Progres Q28/LF1)
- Avast Foundation [0F2016\ 2016020048, SSD2018\ 100022]
- CEZ Foundation [STE EPP 126_16]
- Ministry of Health of the Czech Republic [RVO-VFN 64165, CZ-DRO FNBr 65269705]
- CEPS a.s. [1410001544, 1410002088]
- Charles University, Prague (Progres Q25/LF1)
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Ovarian cancer is the deadliest gynecologic cancer. The large-scale microRNA (miRNA) expression profiling and individual miRNA validation was performed to find potential novel biomarkers for ovarian cancer. The most consistent overexpression of miRs-200b-3p, 135 b-5p and 182-5p was found in both ascitic fluid and tumors and suggests their potential as oncogenes. miR-451a was consistently underexpressed so may be a tumor suppressor. Results were inconsistent for miR-204-5p, which was overexpressed in ascitic fluid but underexpressed in tumor tissue. miR-203a-3p was generally overexpressed but this failed to be proved in independent sample set in tissue validation.
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