Journal
BRAIN RESEARCH
Volume 1717, Issue -, Pages 86-94Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2019.04.012
Keywords
Neuroprotection; Neonatal hypoxia-ischemia; Maternal supplementation; Piceatannol; Magnetic resonance imaging; Behavior
Categories
Funding
- Foundation de Recherche en Alcoologie (FRA) from the French State [2018/01, ANR-10-IDEX, ANR-10-LABX-57]
- Franco-Swiss ANR-FNS [ANR-15-CE37-0012, 310030E-164271]
- program IdEx Bordeaux [ANR-10-IDEX-03-02]
- Swiss National Science Foundation (SNF) [310030E-164271] Funding Source: Swiss National Science Foundation (SNF)
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Hypoxia-ischemia (HI) remains a major cause of perinatal mortality and chronic disability in newborns worldwide (1-6 for 1000 births) with a high risk of future motor, behavioral and neurological deficits. Keeping newborns under moderate hypothermia is the unique therapeutic approach but is not sufficiently successful as nearly 50% of infants do not respond to it. In a 7-day post-natal rat model of HI, we used pregnant and breastfeeding female nutritional supplementation with piceatannol (PIC), a polyphenol naturally found in berries, grapes and passion fruit, as a neuroprotective strategy. Maternal supplementation led to neuroprotection against neonate brain damage and reversed their sensorimotor deficits as well as cognitive impairments. Neuroprotection of per os maternal supplementation with PIC is a preventive strategy to counteract brain damage in pups induced by HI. This nutritional approach could easily be adopted as a preventive strategy in humans.
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