Journal
BIOSENSORS & BIOELECTRONICS
Volume 141, Issue -, Pages -Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2019.111421
Keywords
Biomimetic enzyme; Biosensor; Atomic matching catalysis; Uric acid detection; High selectivity
Categories
Funding
- National Natural Science Foundation of China [31872753, 21605110]
- Institute for Clean Energy & Advanced Materials (Southwest University, Chongqing, China)
- Chongqing Key Laboratory for Advanced Materials & Technologies of Clean Energies [JJNY201903]
- Natural Science research Foundation of Jiangsu Higher Education Institutions
- Natural Science Foundation of Suzhou University of Science and Technology
- Open Foundation of The Jiangsu Key Laboratory for Biochip and Medical diagnosis
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A main challenge for biomimetic non-enzyme biosensors is to achieve high selectivity. Herein, an innovative biomimetic non-enzyme sensor for electrochemical detection of uric acid (UA) with high selectivity and sensitivity is realized by growing Prussian blue (PB) nanoparticles on nitrogen-doped carbon nanotubes (N-doped CNTs). The enhancement mechanism of the biomimetic UA sensor is proposed to be atomically matched active sites between two reaction sites (oxygen atoms of 2, 8-trione, 6.9 angstrom) of UA molecule and two redox centers (Fe-II on the diagonal, 7.2 angstrom) of PB. Such an atomically matching manner not only promotes strong adsorption of UA on PB but also selectively enhances electron transfer between reaction sites of UA and active Fe-II centers of PB. This biomimetic UA sensor can offer great selectivity to avoid interferences from other oxidative and reductive species, showing excellent selectivity. An electrochemical biomimetic sensor based on PB/N-doped CNTs was applied to in situ detect UA in human serum, delivering a wide dynamic detection range (0.001-1 mM) and a low detection limit (0.26 mu M). This work provides a high-performance UA sensor while shedding a scientific light on using atomic matching catalysis to fabricate highly sensitive and selective biomimetic sensors.
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