Journal
BIOORGANIC CHEMISTRY
Volume 90, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2019.103072
Keywords
Marine pufferfish; Type 2 diabetes mellitus; High-fat diet; Streptozotocin; In vitro and in vivo studies; LC-ESI/MS analysis
Funding
- University Grants Commissions/Rajiv Gandhi National Fellowship (UGC/RGNF), New Delhi, Government of India [F1-17.1/2016-17/RGNF-2015-17-SC-TAM-19298/ (SA-III Website)]
- Ministry of Earth Sciences, Govt. of India [MoES/36/OOIS/Extra/9/2013]
- UGC-BSR Faculty Fellowship, University Grants Commission (UGC), India [F.18-1/2011(BSR)]
- Lee Kong Chian School of Medicine, Nanyang Technological University (NTU) Start-Up Grant, Singapore
- NTU Austrian Institute of Technology & Medical University of Vienna internal grant, Singapore [NAM/15005]
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In the present study pufferfish, Arothron immaculatus muscle methanol extract (AIME) was used to evaluate the antidiabetic activity against the high-fat diet (HFD) in streptozotocin (STZ) induced diabetic rat models. Initially, the In vitro antioxidant activity of the different muscle extract was evaluated which showed that AIME has higher efficiency to scavenge the free radicals. The animal study results revealed that the AIME could decrease the blood glucose level after 14 days of oral treatment and recover the animal from the severe progression of the disease. The LC-ESI/MS analysis of AIME extract revealed the presence of compounds such as docosahexaenoic acid, adrenic acid, docosanol, codeine and metoprolol. Among these compounds, docosahexaenoic acid, adrenic acid and docosanol are reported for its antidiabetic studies. Hence, the muscle is recommended to consume by humans as natural food in order to overcome the development of diabetes. This is the first study on the muscle extract of marine pufferfish which is used as antidiabetic agent to treat the diabetes-induced in the animal model.
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