Journal
BIOMICROFLUIDICS
Volume 13, Issue 5, Pages -Publisher
AIP Publishing
DOI: 10.1063/1.5120555
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Funding
- National Research Foundation of Korea (NRF) - Korean Government (MSIT) [2018R1A2A3075013]
- Brain Research Program through the NRF - Ministry of Science and ICT [NRF-2016M3C7A1913845, NRF-2018M3C7A1056896]
- Ministry of Trade, Industry & Energy (MOTIE, Korea) [10067787]
- KIST Institutional Program [2E29200, 2V07460]
- National Research Foundation of Korea [2018R1A2A3075013, 2E29200] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Since the advent of organ-on-a-chip, many researchers have tried to mimic the physiology of human tissue on an engineered platform. In the case of brain tissue, structural connections and cell-cell interactions are important factors for brain function. The recent development of brain-on-a-chip is an effort to mimic those structural and functional aspects of brain tissue within a miniaturized engineered platform. From this perspective, we provide an overview of trace of brain-on-a-chip development, especially in terms of complexity and high-content/ high-throughput screening capabilities, and future perspectives on more in vivo-like brain-on-a-chip development. Published under license by AIP Publishing.
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