Journal
BIOMACROMOLECULES
Volume 20, Issue 10, Pages 3613-3626Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.9b00999
Keywords
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Funding
- China Scholarship Council
- German Research Foundation (DFG) Excellence Cluster Nanosystems Initiative Munich (NIM) [SFB1032, SFB1066]
- UPGRADE (Unlocking Precision Gene Therapy) Project from the European Union's Horizon 2020 research and innovation programme [825825]
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Within the last two decades, a series of novel therapeutic nucleic acids entered research and clinical evaluation. Their differences both in biophysical properties as well as in mode and site of biological action provide polymer-based carriers with new delivery challenges. Recent tailor-made designs of polymeric carriers are reviewed that were optimized for nucleic acid cargos such as plasmid DNA, siRNA, and micro RNA, mRNA, or genome-modifying nucleic acids. The specific requirements for the various therapeutic cargos are discussed. Future directions include dynamic bioresponsive polymers as components of nanomachines, multifunctional sequence-defined carriers for evolution-based selective optimization, and organic inorganic multicomponent nanoassemblies.
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