Journal
BIOINFORMATICS
Volume 36, Issue 3, Pages 936-937Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btz664
Keywords
-
Categories
Funding
- Swedish Research Council [2017-03709]
- Carl Tryggers Foundation [CTS 15:184]
- Vinnova [2017-03709] Funding Source: Vinnova
- Swedish Research Council [2017-03709] Funding Source: Swedish Research Council
Ask authors/readers for more resources
A Summary: Metagenomics and single-cell genomics have revolutionized the study of microorganisms, increasing our knowledge of microbial genomic diversity by orders of magnitude. A major issue pertaining to metagenome-assembled genomes (MAGs) and single-cell amplified genomes (SAGs) is to estimate their completeness and redundancy. Most approaches rely on counting conserved gene markers. In miComplete, we introduce a weighting strategy, where we normalize the presence/absence of markers by their median distance to the next marker in a set of complete reference genomes. This approach alleviates biases introduced by the presence/absence of shorter DNA pieces containing many markers, e.g. ribosomal protein operons.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available