Journal
BIOGERONTOLOGY
Volume 20, Issue 6, Pages 741-761Publisher
SPRINGER
DOI: 10.1007/s10522-019-09832-3
Keywords
Non-coding DNA; DNA damage accumulation; Aging-related diseases; Peripheral heterochromatin; Genome protection
Categories
Funding
- Natural Science Foundation of Fujian Province [2018J01456, 2016J01711]
- Longyan Science and Technology Scheme [2017LY73, 2017LY26]
Ask authors/readers for more resources
Aging is a progressive decline of physiological function in tissue and organ accompanying both accumulation of DNA damage and reduction of non-coding DNA. Peripheral non-coding DNA/heterochromatin has been proposed to protect the genome and centrally-located protein-coding sequences in soma and male germ cells against radiation and the invasion of exogenous nucleic acids. Therefore, this review summarizes the reduction of non-coding DNA/heterochromatin (including telomeric DNA and rDNA) and DNA damage accumulation during normal physiological aging and in various aging-related diseases. Based on analysis of data, it is found that DNA damage accumulation is roughly negatively correlated with the reduction of non-coding DNA and therefore speculated that DNA damage accumulation is likely due to the reduction of non-coding DNA protection in genome defense during aging. Therefore, it is proposed here that means to increase the total amount of non-coding DNA and/or heterochromatin prior to the onset of these diseases could potentially better protect the genome and protein-coding DNA, reduce the incidence of aging-related diseases, and thus lead to better health during aging.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available