Journal
BIOCONJUGATE CHEMISTRY
Volume 30, Issue 9, Pages 2247-2263Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.9b00448
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Funding
- National Institutes of Health [1R01 CA220237-01A1, 2CA136494, CA213278]
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Compared to normal tissues, the tumor micro-environment (TME) has a number of aberrant characteristics including hypoxia, acidosis, and vascular abnormalities. Many researchers have sought to exploit these anomalous features of the TME to develop anticancer therapies, and several nanoparticle-based cancer therapeutics have resulted. In this Review, we discuss the composition and pathophysiology of the TME, introduce nanoparticles (NPs) used in cancer therapy, and address the interaction between the TME and NPs. Finally, we outline both the potential problems that affect TME-based nanotherapy and potential strategies to overcome these challenges.
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