Related references
Note: Only part of the references are listed.Treatment of atopic dermatitis with tralokinumab, an anti-IL-13 mAb
Andreas Wollenberg et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)
Common and different roles of IL-4 and IL-13 in skin allergy and clinical implications
Lennart M. Roesner et al.
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2019)
RPC4046, a Monoclonal Antibody Against IL13, Reduces Histologic and Endoscopic Activity in Patients With Eosinophilic Esophagitis
Ikuo Hirano et al.
GASTROENTEROLOGY (2019)
A Phase 2 Randomized Controlled Study of Tralokinumab in Subjects with Idiopathic Pulmonary Fibrosis
Joseph M. Parker et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)
Cytokine-targeting biologics for allergic diseases
Monica G. Lawrence et al.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2018)
Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids
Ho Jun Lee et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Efficacy and safety of lebrikizumab (an anti-IL-13 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical corticosteroids: A randomized, placebo-controlled phase II trial (TREBLE)
Eric L. Simpson et al.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2018)
Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma
Klaus F. Rabe et al.
NEW ENGLAND JOURNAL OF MEDICINE (2018)
Tralokinumab for severe, uncontrolled asthma (STRATOS 1 and STRATOS 2): two randomised, double-blind, placebo-controlled, phase 3 clinical trials
Reynold A. Panettieri et al.
LANCET RESPIRATORY MEDICINE (2018)
IL-4 Receptor Alpha Signaling through Macrophages Differentially Regulates Liver Fibrosis Progression and Reversal
Shih-Yen Weng et al.
EBIOMEDICINE (2018)
Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions
Clement D. Marshall et al.
ADVANCES IN WOUND CARE (2018)
Biologics and Small Molecule Agents in Allergic and Immunologic Skin Diseases
Bridget P. Kaufman et al.
CURRENT ALLERGY AND ASTHMA REPORTS (2018)
Recent developments in the use of biologics targeting IL-5, IL-4, or IL-13 in severe refractory asthma
Garry M. Walsh
EXPERT REVIEW OF RESPIRATORY MEDICINE (2018)
SAR156597 in idiopathic pulmonary fibrosis: a phase 2 placebo-controlled study (DRI11772)
Ganesh Raghu et al.
EUROPEAN RESPIRATORY JOURNAL (2018)
Type 2 immunity: Expanding our view
Clare M. Lloyd et al.
SCIENCE IMMUNOLOGY (2018)
Type 2 immunity in tissue repair and fibrosis
Richard L. Gieseck et al.
NATURE REVIEWS IMMUNOLOGY (2018)
Commonality of the IL-4/IL-13 pathway in atopic diseases
Namita A. Gandhi et al.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2017)
The IL-4 receptor α has a critical role in bone marrow-derived fibroblast activation and renal fibrosis
Hua Liang et al.
KIDNEY INTERNATIONAL (2017)
Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis
Kelly L. Walton et al.
FRONTIERS IN PHARMACOLOGY (2017)
Immune-Mediated Repair: A Matter of Plasticity
Paôline Laurent et al.
Frontiers in Immunology (2017)
Current Therapeutic Approach to Hypertrophic Scars
Zrinka Bukvic Mokos et al.
FRONTIERS IN MEDICINE (2017)
The Changing Landscape of Alopecia Areata: The Therapeutic Paradigm
Yael Renert-Yuval et al.
ADVANCES IN THERAPY (2017)
RPC4046, A Novel Anti-interleukin-13 Antibody, Blocks IL-13 Binding to IL-13 α1 and α2 Receptors: A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation First-in-Human Study
Catherine S. Tripp et al.
ADVANCES IN THERAPY (2017)
The myofibroblast, a key cell in normal and pathological tissue repair
Ian A. Darby et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2016)
Keloids and Hypertrophic Scars: A Spectrum of Clinical Challenges
Anthony P. Trace et al.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2016)
Transition from inflammation to proliferation: a critical step during wound healing
Ning Xu Landen et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2016)
Novel Biologicals for the Treatment of Allergic Diseases and Asthma
Hern-Tze Tina Tan et al.
CURRENT ALLERGY AND ASTHMA REPORTS (2016)
A Critical Evaluation of Anti-IL-13 and Anti-IL-4 Strategies in Severe Asthma
Diego Bagnasco et al.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2016)
Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis A Randomized Clinical Trial
Claus Bachert et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)
Short-term subcutaneous grass pollen immunotherapy under the umbrella of anti-IL-4: A randomized controlled trial
Adam M. Chaker et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)
TGF-β: the master regulator of fibrosis
Xiao-ming Meng et al.
NATURE REVIEWS NEPHROLOGY (2016)
Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis
E. L. Simpson et al.
NEW ENGLAND JOURNAL OF MEDICINE (2016)
Transforming growth factor beta (TGF-β) isoforms in wound healing and fibrosis
Michael K. Lichtman et al.
WOUND REPAIR AND REGENERATION (2016)
Systemic depletion of macrophages in the subacute phase of wound healing reduces hypertrophic scar formation
Zhensen Zhu et al.
WOUND REPAIR AND REGENERATION (2016)
Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): replicate, phase 3, randomised, double-blind, placebo-controlled trials
Nicola A. Hanania et al.
LANCET RESPIRATORY MEDICINE (2016)
A pharmacokinetic comparison of anrukinzumab, an anti- IL-13 monoclonal antibody, among healthy volunteers, asthma and ulcerative colitis patients
Fei Hua et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2015)
Commentary: IL-4 and IL-13 receptors and signaling
Sarah M. McCormick et al.
CYTOKINE (2015)
Strategies targeting the IL-4/IL-13 axes in disease
Richard D. May et al.
CYTOKINE (2015)
Anrukinzumab, an anti-interleukin 13 monoclonal antibody, in active UC: efficacy and safety from a phase IIa randomised multicentre study
Walter Reinisch et al.
GUT (2015)
Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair
Johanna A. Knipper et al.
IMMUNITY (2015)
Role of anti-inflammatory cytokines IL-4 and IL-13 in systemic sclerosis
Xiao-Lei Huang et al.
INFLAMMATION RESEARCH (2015)
Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis
Marc E. Rothenberg et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)
Scarless Wound Healing: Chasing the Holy Grail
Graham G. Walmsley et al.
PLASTIC AND RECONSTRUCTIVE SURGERY (2015)
Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studies
Nicola A. Hanania et al.
THORAX (2015)
Biologic Therapies Targeting Eosinophils: Current Status and Future Prospects
Fanny Legrand et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2015)
Tralokinumab for moderate-to-severe UC: a randomised, double-blind, placebo-controlled, phase IIa study
Silvio Danese et al.
GUT (2015)
Type 2 cytokines: mechanisms and therapeutic strategies
Thomas A. Wynn
NATURE REVIEWS IMMUNOLOGY (2015)
Future Biologic Therapies in Asthma
Santiago Quirce et al.
ARCHIVOS DE BRONCONEUMOLOGIA (2014)
Efficacy and safety of an anti-IL-13 mAb in patients with severe asthma: A randomized trial
Erika H. De Boever et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)
Interleukin-13-producing CD8+T cells mediate dermal fibrosis in patients with systemic sclerosis
Patrizia Fuschiotti et al.
ARTHRITIS AND RHEUMATISM (2013)
Cytokine mediated tissue fibrosis
Lee A. Borthwick et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2013)
Role of Interleukin-13 in fibrosis, particularly systemic sclerosis
Steven O'Reilly
BIOFACTORS (2013)
The Immune Pathogenesis of Scleroderma: Context Is Everything
Matthew B. Greenblatt et al.
CURRENT RHEUMATOLOGY REPORTS (2013)
The molecular mechanism of hypertrophic scar
Zhensen Zhu et al.
JOURNAL OF CELL COMMUNICATION AND SIGNALING (2013)
IL-13 signaling via IL-13Rα2 triggers TGF-β1-dependent allograft fibrosis
Stefan M. Brunner et al.
TRANSPLANTATION RESEARCH (2013)
Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths
William C. Gause et al.
NATURE REVIEWS IMMUNOLOGY (2013)
Interspecies Comparison of Human and Murine Scleroderma Reveals IL-13 and CCL2 as Disease Subset-Specific Targets
Matthew B. Greenblatt et al.
AMERICAN JOURNAL OF PATHOLOGY (2012)
Targeting Interleukin-4 in Asthma: Lost in Translation?
Tania Maes et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2012)
Cutaneous scarring: Pathophysiology, molecular mechanisms, and scar reduction therapeutics Part I. The molecular basis of scar formation
Christos Profyris et al.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2012)
Cutaneous scarring: Pathophysiology, molecular mechanisms, and scar reduction therapeutics Part II. Strategies to reduce scar formation after dermatologic procedures
Christos Tziotzios et al.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2012)
Extracellular matrix molecules implicated in hypertrophic and keloid scarring
G. P. Sidgwick et al.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2012)
Mechanisms of fibrosis: therapeutic translation for fibrotic disease
Thomas A. Wynn et al.
NATURE MEDICINE (2012)
Effects of Interleukin-13 Blockade on Allergen-induced Airway Responses in Mild Atopic Asthma
Gail M. Gauvreau et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)
Role of IL-13 in systemic sclerosis
Patrizia Fuschiotti
CYTOKINE (2011)
The effects of an anti-IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge
Grant C. Nicholson et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2011)
Recommendations on clinical proof of efficacy for potential scar prevention and reduction therapies
James A. Bush et al.
WOUND REPAIR AND REGENERATION (2011)
Evolution of Th2 Immunity: A Rapid Repair Response to Tissue Destructive Pathogens
Judith E. Allen et al.
PLOS PATHOGENS (2011)
A Randomized, Controlled, Phase 2 Study of AMG 317, an IL-4Rα Antagonist, in Patients with Asthma
Jonathan Corren et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2010)
Animal Models of Systemic Sclerosis Prospects and Limitations
Christian Beyer et al.
ARTHRITIS AND RHEUMATISM (2010)
IL-33 Induces IL-13-Dependent Cutaneous Fibrosis
Andrew L. Rankin et al.
JOURNAL OF IMMUNOLOGY (2010)
Macrophages: Master Regulators of Inflammation and Fibrosis
Thomas A. Wynn et al.
SEMINARS IN LIVER DISEASE (2010)
Effector CD8+ T Cells in Systemic Sclerosis Patients Produce Abnormally High Levels of Interleukin-13 Associated With Increased Skin Fibrosis
Patrizia Fuschiotti et al.
ARTHRITIS AND RHEUMATISM (2009)
Human skin wounds: A major and snowballing threat to public health and the economy
Chandan K. Sen et al.
WOUND REPAIR AND REGENERATION (2009)
Cellular and molecular mechanisms of fibrosis
T. A. Wynn
JOURNAL OF PATHOLOGY (2008)
The hidden cost of skin scars: quality of life after skin scarring
B. C. Brown et al.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY (2008)
Wound repair and regeneration
Geoffrey C. Gurtner et al.
NATURE (2008)
Untangling the Complex Web of IL-4-and IL-13-Mediated Signaling Pathways
Marsha Wills-Karp et al.
SCIENCE SIGNALING (2008)
Effect of an interieukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies
Sally Wenzel et al.
LANCET (2007)
Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection
P'ng Loke et al.
JOURNAL OF IMMUNOLOGY (2007)
Systemic sclerosis: a prototypic multisystem fibrotic disorder
John Varga et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Quality of life of patients with keloid and hypertrophic scarring
O Bock et al.
ARCHIVES OF DERMATOLOGICAL RESEARCH (2006)
Polarized Th2 cytokine production in patients with hypertrophic scar following thermal injury
EE Tredget et al.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2006)
IL-13 signaling through the IL-13 alpha 2 receptor is involved in induction of TGF-beta 1 production and fibrosis
S Fichtner-Feigl et al.
NATURE MEDICINE (2006)
Molecular aspects of regulation of collagen gene expression in fibrosis
RK Bhogal et al.
JOURNAL OF CLINICAL IMMUNOLOGY (2005)
TGF-β signaling and the fibrotic response
A Leask et al.
FASEB JOURNAL (2004)
Interleukin-13 stimulates the transcription of the human α2(I) collagen gene in human dermal fibroblasts
M Jinnin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
IL-13 activates a mechanism of tissue fibrosis that is completely TGF-β independent
M Kaviratne et al.
JOURNAL OF IMMUNOLOGY (2004)
Fibrotic disease and the TH1/TH2 paradigm
TA Wynn
NATURE REVIEWS IMMUNOLOGY (2004)
Transgenic analysis of scleroderma: understanding key pathogenic events in vivo
CP Denton et al.
AUTOIMMUNITY REVIEWS (2004)
Molecular mechanisms of interleukin-4 - Induced up-regulation of type I collagen gene expression in murine fibroblasts
TL McGaha et al.
ARTHRITIS AND RHEUMATISM (2003)
Regulation and function of the interleukin 13 receptor α 2 during a T helper cell type 2-dominant immune response
MG Chiaramonte et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Serum levels of tumor necrosis factor and interleukin-13 are elevated in patients with localized scleroderma
M Hasegawa et al.
DERMATOLOGY (2003)
Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthma
TK Hart et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2002)
Overexpression of IL-4 alters the homeostasis in the skin
A Elbe-Bürger et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2002)
Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-β production by fibroblasts
T Kodera et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor β1
CG Lee et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2001)
Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type-1 and type-2 cytokine-mediated inflammatory reactions
KF Hoffmann et al.
FASEB JOURNAL (2001)
Lack of skin fibrosis in tight skin (TSK) mice with targeted mutation in the interleukin-4R alpha and transforming growth factor-beta genes
T McGaha et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2001)
Implication of interleukin-4 in wound healing
V Salmon-Ehr et al.
LABORATORY INVESTIGATION (2000)
Share Paper
