Journal
APPLIED ORGANOMETALLIC CHEMISTRY
Volume 33, Issue 11, Pages -Publisher
WILEY
DOI: 10.1002/aoc.5171
Keywords
anticancer; half-sandwich; luminescene imaging; ruthenium complexes; triphenylamine
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Funding
- Taishan Scholars Program
- Shandong Provincial Natural Science Foundation, China [ZR2017MB038]
- National Natural Science Foundation of China [21703118, 21603116, 21671118]
- University Research Development Program of Shandong Province [J18KA082]
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Four half-sandwich ruthenium(II) (Ru-II) complexes with triphenylamine-modifed dipyridine frameworks were synthesized and characterized. The cytotoxicity of target complexes toward A549 (lung cancer cells), HeLa (cervical cancer cells) and HepG2 (hepatoma cells) were obtained by the MTT assay, which were superior to cisplatin with the IC50 values changed from 2.4 +/- 0.1 mu M to 9.2 +/- 2.7 mu M. Meanwhile, complexes possess the ability of antimetastasis to cancer cells. Ru-II complexes could be transported by serum albumin, catalyze the conversion of NADH (the reduced state of nicotinamide-adenine dinucleotide) to NAD(+) and induce the accumulation of reactive oxygen species, which confirmed the antineoplastic mechanism of oxidation. Ru-II complexes could enter A549 cells followed by a non-energy dependent cellular uptake mechanism, target lysosomes with the Pearson's colocalization coefficient of 0.75, lead to lysosomal damage, disturb the cell cycle (S phase), and eventually induce apoptosis. The results demonstrate that these Ru-II complexes are potential anticancer agents with dual functions, including metastasis inhibition and lysosomal damage.
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