Journal
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Volume 37, Issue 1, Pages 66-+Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/ATVBAHA.116.308063
Keywords
atherosclerosis; immunology; inflammation; lymphocytes; ultraviolet rays
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Funding
- JSPS [23790849, 25860601, 24591114]
- Japan Heart Foundation
- Astellas/Pfizer Grant for Research on Atherosclerosis Update
- Kimura Memorial Heart Foundation
- Japan Heart Foundation/Novartis Grant for Research Award on Molecular and Cellular Cardiology
- Global Center of Excellence
- Banyu Life Science Foundation International
- Suzuken Memorial Foundation
- ONO Medical Research Foundation
- Takeda Scientific Foundation
- Senshin Medical Research Foundation
- Mitsui Life Social Welfare Foundation
- Yakult Bioscience Research Foundation
- Uehara Memorial Foundation
- Japan Circulation Society Translational Research Foundation
- Grants-in-Aid for Scientific Research [15K08530, 23790849, 25860601, 16H06295, 24591114] Funding Source: KAKEN
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Objective-UVB irradiation is an established treatment for immunoinflammatory cutaneous disorders and has been shown to suppress cutaneous and systemic inflammatory diseases through modulation of the adaptive immune response. However, it remains unknown whether UVB irradiation prevents an immunoinflammatory disease of arteries such as atherosclerosis. Approach and Results-Here, we show that UVB exposure inhibits the development and progression of atherosclerosis in atherosclerosis-prone mice by expanding and enhancing the functional capacity of CD4(+) forkhead box P3(+) regulatory T cells and regulating proatherogenic T-cell responses. Experimental studies in Langerhans cell-depleted mice revealed that epidermal Langerhans cells play a critical role in UVB-dependent induction of CD4(+) forkhead box P3(+) regulatory T cells, suppression of proatherogenic T-cell responses, and prevention of atherosclerotic plaque development. Conclusions-Our findings suggest the skin immune system as a novel therapeutic target for atherosclerosis and provide a novel strategy for the treatment and prevention of atherosclerosis.
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