Journal
ANALYTICAL CHEMISTRY
Volume 91, Issue 19, Pages 12181-12190Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.9b01068
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Funding
- National Research Foundation - Korean government (MSIT) [NRF-2018R1A2B3004498]
- KIST Institutional Program [2E29530]
- National Research Council of Science and Technology (NST) Grant by the Korea government (MSIP) [CRC-16-01-KRICT]
- Korea Basic Science Institute [D38410]
- Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET) through the Advanced Production Technology Development Program - Ministry of Agriculture, Food and Rural Affairs (MAFRA) [318104-3]
- National Research Foundation of Korea [2E29530] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Field-effect transistor (FET) devices based on conductive nanomaterials have been used to develop biosensors. However, development of FET-based biosensors that allow efficient stability, especially in the gas phase, for obtaining reliable and reproducible responses remains a challenge. In this study, we developed a nanodisc (ND)-functionalized bioelectronic nose (NBN) based on a nickel (Ni)-decorated carboxylated polypyrrole nanoparticle (cPPyNP)-FET that offers the detection of liquid and gaseous cadaverine (CV). The TAAR13c, specifically binding to CV, which is an indicator of food spoilage, was successfully constructed in NDs. The NBN was fabricated by the oriented assembly of TAAR13c-embedded NDs (T13NDs) onto the transistor with Ni/cPPyNPs. The NBN showed high performance in selectivity and sensitivity for the detection of CV, with excellent stability in both aqueous and gas phases. Moreover, the NBN allowed efficient measurement of corrupted real-food samples. It demonstrates the ND-based device can allow the practical biosensor that provides high stability in the gas phase.
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