Journal
ANALYTICAL CHEMISTRY
Volume 91, Issue 19, Pages 12453-12460Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.9b03143
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Funding
- U.S. National Institutes of Health [GM079359, CA133086]
- National Natural Science Foundation of China [21505084, 21775089, 21475074]
- Natural Science Foundation Projects of Shandong Province [ZR2014BM029, ZR2013BQ019]
- Key Research and Development Program of Shandong Province [2017GSF19109]
- Innovation Project of Shandong Graduate Education [SDYY16091]
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Ferric ion (Fe3+) plays a vital role in cellular homeostasis. However, the detection of Fe3+ with rhodamine B (RhB) has potential problems, such as poor selectivity and low photostability. To address these problems, we rationally designed an RhB@MOF nanocomposite-based on-off-on fluorescent switching nanoprobe for highly sensitive and selective detection of Fe3+ and ascorbic acid. This RhB@MOF nanoprobe was prepared through a facile one-pot synthesis. Here MOF served as a selectivity regulator for the detection of Fe3+. By embedding RhB into the porous crystalline MOF, enhanced photostability and fluorescence lifetime of RhB to Fe-3(+)- were achieved. The as-prepared RhB@MOF was demonstrated to be an ultrasensitive and selective nanoprobe for the detection of Fe(3+ )in human serum and ascorbic acid in rat brain microdialysate. Furthermore, inner filter effect (IFE) and photoinduced electron transfer (PET) were proposed and discussed to explain the selectivity and sensitivity of RhB to Fe(3+ )against other interfering substances. Our novel on-off-on nanoprobe provides insight into the rational design of MOF-based biosensors for selective and sensitive detection of analytes.
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