Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 411, Issue 26, Pages 7039-7049Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-019-02081-w
Keywords
MALDI-TOF MS; Magnetic solid-phase extraction; Graphene oxide; Quinolones; High-throughput screening; Magnetic composites
Funding
- the Tianjin Scientific and Technology Support Program Funding Agency [16YFZCNC00730] Funding Source: Medline
- the National Key R&D Program of China [2017YFF0211301] Funding Source: Medline
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Antibiotic compounds in natural waters are normally present at low concentrations. In this paper, an easy and highly sensitive screening method using graphene oxide-functionalized magnetic composites (GO@NH2@Fe3O4) combined with matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS) was established for twelve quinolone antibiotics. GO@NH2@Fe3O4 composites were utilized as adsorbents for magnetic solid-phase extraction. This method combines the advantages of magnetic solid-phase extraction and MALDI-TOF MS, which allows for fast detection of quinolones at low concentrations. To improve absorption efficiency, the following parameters were individually optimized: sample acidity, extraction time, amount of adsorbent used, eluent used, and desorption time. Under the optimum conditions, the established method gave a low detection limit of 0.010 mg/L and allowed the high-throughput screening of twelve quinolone antibiotics (enoxacin, norfloxacin, ciprofloxacin, pefloxacin, fleroxacin, gatifloxacin, enrofloxacin, levofloxacin, sparfloxacin, danofloxacin, difloxacin, and lomefloxacin). The proposed method, having an easily prepared sorbent with a high affinity for quinolones and a convenient, high-throughput detection step, has been shown to have merit for the detection of antibiotics in water samples
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