Journal
ANALYTICA CHIMICA ACTA
Volume 1068, Issue -, Pages 18-27Publisher
ELSEVIER
DOI: 10.1016/j.aca.2019.04.015
Keywords
Water-soluble pillar[6]arene; Mimetic enzymes; PdPt porous core-shell octahedral nanodendrites; Neuron-specific enolase immunosensor; Host-guest molecular recognition
Categories
Funding
- National Natural Science Foundation of China [21864024, 51764051]
- Program for Leading Talents, Department of Science and Technology of Yunnan Province [2017HA013]
- Basic Research Project of Science and Technology Commission of Chongqing [cstc2017jcyjA0656, cstc2017jcyjAX0031]
Ask authors/readers for more resources
In this work, water-soluble pillar[6]arene functionalized PdPt porous core-shell octahedral nano-dendrites (WP6@PdPt PCONs) were simply synthesized and used for the fabrication of NSE immunosensor. The newest generation of macrocyclic host and biomimetic nano-enzymes have been effectively integrated to achieve the robust immobilization of signal molecules by host-guest molecular recognition and sensitively catalytic amplification of electrochemical signals. The addition of Pd and the formation of WP6@PdPt PCONs unique bimetallic nanostructure are beneficial to changing Pt-based catalyst electronic structure, accelerating the electron transport, promoting the generation of synergistic catalysis effect. Compared with enzyme-based methods, the fabricated sandwich-type immunosensor demonstrates more advantages in robustness owing to the introduction of host-guest chemistry and biomimetic nano-enzymes. In the wide range from 0.0003 to 100.00 ng mL(-1), a good linear relationship (R-2 = 0.998) and a low LOD (0.095 pg mL(-1), S/N = 3) can be obtained. The proposed immunosensor shows remarkable analytical performances in the measurements of selectivity, stability, reproducibility, and real sample analysis, which provided a promising approach for clinical detection of NSE in human serum. Besides, the successful synthesis of WP6@PdPt PCONs provides a new idea for the preparation of biosensors based on bionic materials, nanotechnology and host-guest molecule recognition. (C) 2019 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available