Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 23, Issue 23, Pages 7359-7365Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2015.10.023
Keywords
Bcl-2; Imidazolidine-2,4-dione; Inhibitors; Antitumor
Funding
- National Natural Science Foundation of China [21172133]
- Shandong Natural Science Fund for Distinguished Young Scholars [JQ201319]
- Program for New Century Excellent Talents in University [NCET-12-0337]
Ask authors/readers for more resources
Anti-apoptotic B-cell lymphoma-2 (Bcl-2) proteins are promising targets for cancer therapy. In the present study, a series of imidazolidine-2,4-dione derivatives were designed and synthesized to test their inhibitory activities against anti-apoptotic Bcl-2 proteins. Among them, compound 8k had better growth inhibitory effects on K562 and PC-3 cell lines compared to lead compound WL-276. (C) 2015 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
