Journal
AGING-US
Volume 11, Issue 15, Pages 5498-5517Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/aging.102134
Keywords
endocrine-disrupting compound; EDC; age acceleration; DNA methylation age; sex-specific; brominated flame retardant
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Funding
- National Institute of Environmental Health Sciences (NIEHS) [R01ES024790, R01ES025775, R24ES028528, P30ES019776]
- National Institute of General Medical Sciences [T32GM008490]
- Emory Integrated Genomics Core (EIGC) - Emory University School of Medicine
- Georgia Clinical & Translational Science Alliance of the National Institutes of Health [UL1TR002378]
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Advanced age increases risk for cancer, cardiovascular disease, and all-cause mortality. However, people do not age at the same rate, and biological age (frequently measured through DNA methylation) can be older than chronological age. Environmental factors have been associated with the rate of biological aging, but it is not known whether persistent endocrine-disrupting compounds (EDCs) like polybrominated biphenyl (PBB) would associate with age acceleration. Three different epigenetic age acceleration measures (intrinsic, extrinsic, and phenotypic) were calculated from existing epigenetic data in whole blood from a population highly exposed to PBB (N=658). Association between serum PBB concentration and these measures was tested, controlling for sex, lipid levels, and estimated cell type proportions. Higher PBB levels associated with increased age acceleration (intrinsic: beta=0.24, 95% CI=0.01-0.46, p=0.03; extrinsic: beta=0.39, 95% CI=0.12-0.65, p=0.004; and phenotypic: beta=0.30, 95% CI=0.05-0.54, p=0.01). Neither age when exposed to PBB nor sex statistically interacted with PBB to predict age acceleration, but, in stratified analyses, the association between PBB and age acceleration was only in people exposed before finishing puberty and in men. This suggests that EDCs can associate with the biological aging process, and further studies are warranted to investigate other environmental pollutants' effect on aging.
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