Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 29, Issue 44, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201905124
Keywords
antiaggregation; fluorescent lifetime; migration barrier; quantum yield; viscosity confinement
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Funding
- National Natural Science Foundation of China [81771836, 81501473, 81601502]
- Guangxi Collaborative Innovation Center of Biomedicine [GCICB-SR-201703]
- Fostering Project of Shanghai Municipal Commission of Health and Family Planning for Excellent Young Medical Scholars [2018YQ31]
- Shanghai Science and Technology Committee Rising-Star Program [19QA1406800]
- Key Project of National Natural Science Foundation of China [81430055]
- Opening Project of Guangxi Key Laboratory of Bio-targeting Theranostics [GXSWBX201801]
- Opening Project of State Key Laboratory of High Performance Ceramics and Superfine Microstructure [SKL201811SIC]
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Low quantum yield and aggregation-mediated quenching are two concerns for fluorescence imaging. However, there are not yet general means available for addressing these issues. Herein, a viscosity confinement-mediated antiaggregation strategy is established to enable the improved fluorescence properties of entrapped fluorophores in dye-encapsulation nanotechnology including quantum yield, fluorescence lifetime, and photostability. To instantiate this strategy, solid DL-menthol (DLM) is introduced to disperse entrapped indocyanine green (ICG) fluorophores when coencapsulating DLM and ICG molecules in organic poly(lactic-co-glycolic acid) carriers. Depending on the robust ability of highly viscous DLM to augment the migration barrier and diminish diffusion coefficient, ICG aggregation and aggregation-mediated quenching are demonstrated to be theoretically and experimentally inhibited, resulting in prolonged fluorescence lifetime, increased quantum yield, and facilitated radiative process. Consequently, the fluorescence imaging ability and photostability are significantly improved, enabling the in vitro, cellular-level, and in vivo fluorescence imaging. More significantly, this solid DLM-mediated antiaggregation strategy can act as a general method to extend to the intermolecular fluorescence resonance energy transfer (FRET) process and improve FRET efficiency via inhibiting the aggregation-mediated quenching.
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