Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 29, Issue 45, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201903609
Keywords
laser desorption ionization (LDI); mass spectrometry imaging (MSI); silicon nanostructures; surface functionalization
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Funding
- Spanish Ministry of Economy and Competitivity (MINECO) [TEC2015-69076-P, BES-2016-076483]
- Spanish Ministry of Science, Innovation and Universities (MICIN) [RTI2018-096061-B-I00, IJCI-2017-33438]
- Agency for Management of University and Research Grants of the Catalan Government (AGAUR) [2017-SGR-1119]
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Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is widely used in the biomedical field for the label-free analysis of molecules such as drugs, lipids, peptides, proteins, and biological tissues for molecular imaging. However, organic matrices used in traditional MALDI-MS applications introduce excessive interferences in the low m/z range. For this reason, nanostructured materials-and in particular silicon-based LDI strategies-have become a promising alternative, since they provide a much weaker background. Herein, the recent developments in fabrication, functionalization, and practical applications of silicon-based LDI-MS methods are reviewed. Also the basic requirements of silicon-based substrates for optimal LDI analysis by providing an overview of the LDI mechanisms that use silicon-based substrates instead of organic matrices are reported. Finally, the considerable potential of silicon-based substrates is discussed, giving suggestions for topics for future research.
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