Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 29, Issue 45, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201903850
Keywords
hydroxyl free radical; MR and CT imaging; non-Fenton-type; photothermal therapy; sequential targeted
Categories
Funding
- National Natural Science Foundation of China [21874008, 21727815]
- Major Program of the National Natural Science Foundation of China [21890740, 21890742]
- Fundamental Research Funds for the Central Universities [FRF-TP-17-050A1, FRF-TP-18-007B1, FRF-BR-17-050A1]
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Here, in terms of the highly reactive oxidative hydroxyl radical (center dot OH) generation ability of isoniazid (INH) catalyzed by Mn2+ ion and the photothermal effect of WSSe nanoflakes, a WSSe/MnO2-INH nanocomposite for synergistic anticancer treatment is developed. Advanced INH-induced center dot OH formation ability is systemically demonstrated in the presence of manganese and relevant non-Fenton-type mechanism, and good photothermal conversion efficiency of the WSSe/MnO2 nanocomposite. After modifying with mitochondria-targeted triphenylphosphonium bromide (TPP) moieties and camouflaging with cancer cells membrane (WSSe/MnO2-INH-TPP@CM), it confers a sequential cell-to-mitochondria targeting ability. In vivo X-ray computed tomography and magnetic resonance tumor imaging capability of the nanocomposite are also revealed. The mitochondria-targeted oxidative damage and photothermal therapy by WSSe/MnO2-INH-TPP@CM results in excellent anticancer treatment efficacy both in vitro and in vivo. This is the first exploration of the possibility of non-Fenton-type center dot OH formation for anticancer treatment, which opens new opportunities for ROS-based and combined cancer treatment strategies.
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