Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 29, Issue 44, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201905013
Keywords
chemodynamic therapy; Fenton reaction; photodynamic therapy; tumor hypoxia; tumor microenvironment
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Funding
- National Key Research and Development Program of China [2017YFE0131700]
- National Natural Science Foundation of China [21575095, 21874096, 31900990, 31671024]
- Collaborative Innovation Center of Suzhou Nano Science and Technology (the 111 Project, PAPD)
- Joint International Research Laboratory of Carbon-Based Materials and Devices
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Tumors have adapted various cellular antidotes and microenvironmental conditions to subsist against photodynamic therapy (PDT) and chemodynamic therapy (CDT). Here, the development of reactive oxygen species (ROS)-activatable liposomes (RALP) for therapeutic enhancement by simultaneously addressing the critical questions in PDT and CDT is reported. The design of RALP@HOC@Fe3O4 features ROS-cleavable linker molecules for improved tumor penetration/uptake and ondemand cargo releasing, and integration of Fe3O4 and an oxaliplatin prodrug for smart regulation of hypoxia tumor microenvironment. Glutathione stored by the tumor cells is consumed by the prodrug to produce highly toxic oxaliplatin. Depletion of glutathione not only avoids the undesired annihilation of ROS in PDT, but also modulates the chemical specie equilibria in tumors for H2O2 promotion, leading to greatly relieved tumor hypoxia and PDT enhancement. Synergistically, Fe (II) in the hybrid RALP formulation can be fuelled by H2O2 to generate center dot OH in the Fenton reaction, thus elevating CDT efficiency. This work offers a strategy for harnessing smart, responsive, and biocompatible liposomes to enhance PDT and CDT by regulating tumor microenvironment, highlighting a potential clinical translation beneficial to patients with cancer.
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