Journal
ACS NANO
Volume 13, Issue 10, Pages 10980-10990Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.9b02160
Keywords
allomelanin; DHN melanin; synthetic melanin; radical scavenging activity; radiation protection
Categories
Funding
- MUM through the Air Force Office of Scientific Research [AFOSR 17RT0080]
- Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource [NSF ECCS-1542205]
- MRSEC program at the Materials Research Center [NSF DMR-1720139]
- International Institute for Nanotechnology (IIN)
- State of Illinois, through the IIN
- MM program [NSF DMR-1229693]
Ask authors/readers for more resources
Allomelanin is a type of nitrogen-free melanin most commonly found in fungi. Its existence enhances resistance of the organisms to environmental damage and helps fungi survive harsh radiation conditions such as those found on spacecraft and inside contaminated nuclear power plants. We report the preparation and characterization of artificial allomelanin nanoparticles (AMNPs) via oxidative oligomerization of 1,8-dihydroxynaphthalene (1,8-DHN). We describe the resulting morphological and size control of AMNPs and demonstrate that they are radical scavengers. Finally, we show that AMNPs are taken up by neonatal human epidermal keratinocytes and packaged into perinuclear caps where they quench reactive oxygen species generated following UV exposure.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
