Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 11, Issue 40, Pages 37121-37129Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b12889
Keywords
photodynamic therapy; upper critical solution temperature; porphyrin; block copolymer; IR780; fluorescence resonance energy transfer
Funding
- National Natural Science Foundation of China [21574039, 21875063]
- Shanghai Natural Science Foundation [18ZR1408300]
Ask authors/readers for more resources
Activatable photodynamic therapy (A-PDT) has attracted great attention in precision medicine, which can be activated by endogenous or exogenous stimuli to selectively produce reactive oxygen species (ROS) at the disease site. Thermal responsive polymers with a lower critical solution temperature (LCST) have normally been utilized for constructing A-PDT system. Herein, we fabricated a photothermal activatable photosensitizer (A-PS) by the combination of thermal responsive porphyrin-containing P(AAm-co-AN-co-TPP)-b-PO-EGMA amphiphilic block copolymer with an upper critical solution temperature (UCST) of 42 degrees C and a cyanine dye of IR780. The photoactivity of porphyrin units could be severely inhibited by IR780 due to the fluorescence resonance energy transfer (FRET) from TPP to IR780 during blood circulation process (OFF state). After an uptake by A549 cells and then irradiated with 808 nm laser, A-PS nanoparticles were subsequently dissociated owing to the increased local temperature above the UCST of the polymer chains by excellent photothermal conversion of IR780, resulting in the enhanced photoactivity of TPP (ON state) and the remarkable antitumor effect. Therefore, the UCST-based A-PS extended the biological application of thermal responsive polymers, which may provide a new insight into the design of smart cancer therapeutic systems.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available