Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 11, Issue 38, Pages 34736-34743Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b12643
Keywords
A. pernyi silk fibroin films; polydopamine coating; cell adhesion; wound dressings; skin tissue repair
Funding
- National Natural Science Foundation of China [31800807]
- Zhejiang Provincial Natural Science Foundation of China [LZ17C170002]
- National Postdoctoral Science Foundation of China [2018M632483]
- Fundamental Research Funds for the Central Universities [2018XZZX001-11]
- State of Sericulture Industry Technology System [CARS-18-ZJ0501]
- Zhejiang Provincial Science and Technology Plans [2016C02054-19]
Ask authors/readers for more resources
Wound dressings are important materials for the successful recovery of skin trauma. Traditional wound dressings such as gauzes are not efficient in wound healing. Here we show that silk fibroin, spun from a wild silkworm Antheraea pernyi (A. pernyi) and rich in Arg-Gly-Asp (RGD) sequences, can be developed into a wound dressing after proper modification for improving the cell adhesion to accelerate the skin repair. Specifically, polydopamine (PDA) was coated on an A. pernyi silk fibroin (AF) film to form the PAF film to achieve enhanced cell adhesion and would healing. The PDA coating significantly increased the roughness and hydrophilicity of the AF film and thus its protein absorption capability. Furthermore, the PAF films promoted the adhesion and migration of mesenchymal stem cells (MSCs) in the in vitro wound healing assay. In vivo testing confirmed that wound covered with the PAF film was completely healed with the formation of the new skin and hair within 14 days post trauma. Histological examination indicated that, compared to the AF film and gauze control, the PAF film did not cause significant inflammation in the wound but promoted the epithelialization and well-organized collagen deposition in the dermis. This work indicates that AF films coated with PDA are promising wound dressings for skin tissue repair.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available