Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 11, Issue 39, Pages 36141-36153Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b13271
Keywords
electrospun aligned nanofibers; tazarotene; poly-caprolactone; angiogenesis; drug delivery; wound healing
Funding
- National Natural Science Foundation of China [81601613, 81771122, 81970985, 81970984]
- Key research program of Sichuan Science and technology Department [20185Z0037]
- Medical Science and Technology Project of Zhejiang Province [2016KYB230]
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Wound treatment is a long-lasting clinical issue. Poor angiogenesis leading to delayed wound closure causes huge challenges for healing. Functional electrospun membranes have been established as an efficient strategy to promote wound recovery by protecting and improving vascular regeneration. Here, we aimed to investigate the effect of tazarotene, an active drug for angiogenesis, loaded in aligned electrospun nanofibrous barrier on a soft tissue wound. This aligned membrane was arranged in a single direction, and tazarotene could be released from its nanofibers sustainably. The in vitro study demonstrated that compared with the random drug-loaded or other control groups, the aligned tazarotene-loaded membranes [polycaprolactone (PCL)/AT] could stimulate proliferation, migration, angiogenesis, and vascular endothelial growth factor secretion and its gene expression of human umbilical vein endothelial cells. Furthermore, the in vivo model showed that the prepared tazarotene-loaded aligned membrane significantly accelerated the speed of healing, improved the neovascularization and re-epithelialization, and inhibited the inflammatory reaction in the wound area. All these results above indicated that the PCL/AT nanofibrous dressing, which could promote angiogenesis because of both stimulation of structure and chemical signals, is a promising wound-caring material.
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