Journal
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
Volume 64, Issue -, Pages S117-S122Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00005-016-0436-4
Keywords
Non-small cell lung carcinoma; Endoplasmic reticulum aminopeptidase-1; Genetic association
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Funding
- Polish National Science Centre [N402685040, 2014/15/B/NZ5/03517]
- Association Foundation Program of the Yunnan Provincial Science and Technology Department and Kunming Medical University [2012FB064]
- Foundation Program of the Yunnan Provincial Science and Technology Department [2013FZ131]
- Foundation Program of the Yunnan Province [2014NS139]
- Specialized Research Fund for the Doctoral Program of Higher Education [2012IPB107]
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An effective cytotoxic immune response to neoplastic cells requires efficient presentation of antigenic peptides to T lymphocytes by HLA class I (HLA-I) molecules. The HLA-I-bound peptide repertoire depends on antigen-processing machinery molecules. Aminopeptidase residing in endoplasmic reticulum 1 (ERAP1) trims peptides to the optimal length for HLA-I binding. Single nucleotide polymorphisms (SNPs) in the ERAP1 gene result in changes in aminopeptidase activity and specificity. This may affect susceptibility to cancer. However, non-small cell lung carcinoma (NSCLC) has not been studied in this respect. We compared genotype and haplotype frequencies of four coding, nonsynonymous ERAP1 SNPs, rs26653G > C, rs26618T > C, rs30187C > T, and rs27044C > G, in NSCLC occurring in two genetically distant populations, Chinese and Poles. We found associations of all four SNPs with NSCLC in Chinese but not in Poles. The differences in ERAP1-NSCLC associations might be explained by highly significant differences in SNP genotype frequencies between Chinese and Poles (except for rs26618). In accordance with this, the most frequent ERAP1 haplotypes were distributed differently in cases versus controls in Chinese, but not in Poles. Our findings add to the differences between Orientals and Caucasians in genetics of disease susceptibility.
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