Journal
PLANTS-BASEL
Volume 8, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/plants8040109
Keywords
polyamines; spermidine; thermospermine; nonsense-mediated decay; no-go decay; non-stop decay; quality control; translation
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Funding
- Spanish Ministry of Science, Innovation and Universities [BIO2015-70483-R]
- Generalitat Valenciana grant [VALi+d GVA APOSTD/2017/039]
- EMBO short-term fellowship [STF-7308]
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Plant polyamines (PAs) have been assigned a large number of physiological functions with unknown molecular mechanisms in many cases. Among the most abundant and studied polyamines, two of them, namely spermidine (Spd) and thermospermine (Tspm), share some molecular functions related to quality control pathways for tightly regulated mRNAs at the level of translation. In this review, we focus on the roles of Tspm and Spd to facilitate the translation of mRNAs containing upstream ORFs (uORFs), premature stop codons, and ribosome stalling sequences that may block translation, thus preventing their degradation by quality control mechanisms such as the nonsense-mediated decay pathway and possible interactions with other mRNA quality surveillance pathways.
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