Journal
PATHOGENS
Volume 8, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/pathogens8020076
Keywords
Babesia; persistent infection; antigenic variation; cytoadhesion; immunodominance; immune evasion
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Cattle infected with Babesia bovis face a bifurcated fate: Either die of the severe acute infection, or survive and carry for many years a highly persistent but generally asymptomatic infection. In this review, the author describes known and potential contributions of three variable or highly variant multigene-encoded families of proteins to persistence in the bovine host, and the mechanisms by which variability arises among these families. Ramifications arising from this variability are discussed.
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