4.5 Review

Fungal-Bacterial Interactions in Health and Disease

Journal

PATHOGENS
Volume 8, Issue 2, Pages -

Publisher

MDPI
DOI: 10.3390/pathogens8020070

Keywords

mycobiome; microbiome; cross-kingdom interactions; polymicrobial; commensals; synergism; antagonism; mixed infections

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Funding

  1. DFG FungiNet Project C5 [TRR 124]
  2. Center for Sepsis Care and Control (CSCC)
  3. Jena School for Microbial Communication (JSMC)
  4. International Leibniz Research School (ILRS)

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Fungi and bacteria encounter each other in various niches of the human body. There, they interact directly with one another or indirectly via the host response. In both cases, interactions can affect host health and disease. In the present review, we summarized current knowledge on fungal-bacterial interactions during their commensal and pathogenic lifestyle. We focus on distinct mucosal niches: the oral cavity, lung, gut, and vagina. In addition, we describe interactions during bloodstream and wound infections and the possible consequences for the human host.

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