Journal
JOURNAL OF PHARMACEUTICAL ANALYSIS
Volume 9, Issue 2, Pages 71-76Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpha.2018.11.002
Keywords
Necroptosis; Inhibitors; Drug screening; Target identification; Review
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Funding
- National Natural Science Foundation of China [81503039]
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Apoptosis has been considered as the only form of regulated cell death for a long time. However, a novel form of programmed cell death called necroptosis was recently reported. The process of necroptosis is regulated and plays a critical role in the occurrence and development of multiple human diseases. Thus, the study on the molecular mechanism of necroptosis and its effective inhibitors has been an attractive field for researchers. Herein, we introduce the molecular mechanism of necroptosis and focus on the literature about necroptosis drug screening in recent years. In addition, the identification of the critical drug targets of the necroptosis is also discussed. (C) 2019 Xi'an Jiaotong University. Production and hosting by Elsevier B.V.
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