Journal
BIOMOLECULES
Volume 9, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/biom9060225
Keywords
marine actinobacteria; chemodiversity; antibacteria; anticancer; halometabolites
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Funding
- TWAS for Individual Scientific Research Grant [11-189RG/CHE/AS]
- Higher Education Research Grant Indonesia (Hibah Penelitian Unggulan Perguruan Tinggi Negeri)
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Natural halogenated compounds (halometabolites) are produced mainly by marine organisms, including marine Actinobacteria. Many commercially important compounds for pharmaceuticals contain halogen, and the halogen is responsible for the physical and chemical properties as well as bioactivities and toxicities. In the exploration of marine environment that is supported by advanced structure elucidation, varied panel bioassays and high-throughput screening have accelerated number of halometabolites isolated from marine Actinobacteria to date. The metabolites exhibited unique structures and promising bioactivities. This review focuses on the chemodiversity and bioactivities of marine halometabolites from marine Actinobacteria reported in the last 15 years (2003-2018).
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